The 2000 NFL college draft took place in New York on the weekend of April 15-16, 2000.
| Round | Pick | Overall | Selection/Notes |
| 1 | 17 | 17 | PK Sebastian Janikowski, Florida State |
| 2 | 16 | 47 | WR Jerry Porter, West Virginia |
| 3 | — | — | To Pittsburgh for two '99 5th-round picks |
| 4 | 13 | 107 | DT Junior Ioane, Arizona State |
| 5 | 13 | 142 | P Shane Lechler, Texas A&M |
| 6 | — | — | To Philadelphia for QB Bobby Hoying |
| 7 | 21 | 227 | TE Mondriel Fulcher, Miami |
| 7 | 25 | 231 | S Cliffton Black,
Southwest Texas State From Washington through Denver and Seattle |
Sources: ESPN.com, NFL Draft.Net
Last updated Monday, April 17, 2000